Madrigal Expands its MASH Pipeline with Exclusive Global License Agreement for Ervogastat, a Phase 2 Oral DGAT-2 Inhibitor
01/09/2026 08:00 AM • Madrigal Pharmaceuticals announced an exclusive global license agreement with Pfizer to develop ervogastat, a Phase 2 oral DGAT-2 inhibitor for MASH treatment. The deal includes a $50 million upfront payment to Pfizer, with ervogastat positioned as a complementary therapy to Madrigal's approved drug Rezdiffra for potential combination treatment. Madrigal plans to conduct drug-to-drug interaction studies and consult with the FDA on Phase 2 combination trial design in 2026.
MDGL - Madrigal secured an exclusive global license for a promising Phase 2 asset (ervogastat) that complements its approved drug Rezdiffra, strengthening its pipeline and positioning the company for combination therapy development. This strategic expansion demonstrates confidence in the company's MASH treatment leadership and provides multiple value creation opportunities through milestone payments and royalties.